Kendall , Edward Calvin

Kendall , Edward Calvin
(1886–1972) American biochemist
Kendall, a dentist's son from South Norwalk, Connecticut, studied chemistry at Columbia University where he obtained his PhD in 1910. After working briefly at St. Luke's Hospital in New York from 1911 to 1914, Kendall moved to the Mayo Foundation in Rochester, Minnesota, where from 1921 to 1951 he served as professor of physiological chemistry.
In 1914 Kendall achieved an early success by isolating the active constituent of the thyroid gland. The importance of hormones in the physiology of the body had become apparent through the work of William Bayliss and Ernest Starling on the pancreas. Kendall was able to demonstrate the presence of a physiologically active compound of the amino acid tyrosine and iodine, which he named thyroxin.
Kendall was led from this to investigate the more complex activity of the adrenal gland. This gland secretes a large number of steroids, many of which he succeeded in isolating. Four compounds, labeled A, B, E, and F, seemed to possess significant physiological activity. They were shown to affect the metabolism of proteins and carbohydrates and in their absence animals seemed to lose the ability to deal with toxic substances. It was therefore hoped that some of these compounds might turn out to be therapeutically useful. After much effort sufficient compound A was obtained but, to Kendall's surprise and disappointment, it was shown to have little effect on Addison's disease, a complaint caused by a deficient secretion from the adrenal cortex. Kendall was more successful with his compound E – later known as cortisone to avoid confusion with vitamin E – when in 1947 a practical method for its production was established. Clinical trials showed it to be effective against rheumatoid arthritis. It was for this work that Kendall shared the 1950 Nobel Prize for physiology or medicine with Tadeus Reichstein and Philip Hench.

Scientists. . 2011.

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  • Kendall,Edward Calvin — Kendall, Edward Calvin. 1886 1972. American biochemist. He shared a 1950 Nobel Prize for discoveries concerning the hormones of the adrenal cortex. * * * …   Universalium

  • Kendall, Edward Calvin — ▪ American chemist born March 8, 1886, South Norwalk, Conn., U.S. died May 4, 1972, Princeton, N.J.  American chemist who, with Philip S. Hench (Hench, Philip Showalter) and Tadeus Reichstein (Reichstein, Tadeus), won the Nobel Prize for… …   Universalium

  • Kendall, Edward Calvin — ► (1886 1972) Químico estadounidense. Fue premio Nobel de Medicina y Fisiología en 1950, compartido con P. S. Hench y T. Reichstein, por aislar la tiroxina y descubrir la cortisona y varias hormonas …   Enciclopedia Universal

  • Edward Calvin Kendall — Pour les articles homonymes, voir Kendall. Edward Calvin Kendall (8 mars 1886 4 mai 1972) est un chimiste américain qui a partagé avec Tadeusz Reichstein et Philip Showalter Hench le prix Nobel de physiologie ou médecine de 1950[1 …   Wikipédia en Français

  • Edward Calvin Kendall — Saltar a navegación, búsqueda Edward Calvin Kendall (8 de marzo de 1886 – 4 de mayo de 1972) fue un químico bioquímico americano. Trabajó, como investigador, en distintos hospitales y universidades. Aisló la homona de la glándula tiroides, a la… …   Wikipedia Español

  • Edward Calvin Kendall — (* 8. März 1886 in South Norwalk, Connecticut, USA; † 4. Mai 1972 in Princeton, New Jersey, USA) war ein US amerikanischer Biochemiker. Kendall gelang die Isolation des Nebennierenhormons Cortison und des Schilddrüsenhormons Thyroxin. Für ihre… …   Deutsch Wikipedia

  • Edward Calvin Kendall — Princeton, NJ, USA alma mater = Columbia University fields = Biochemistry workplaces = Parke Davis St. Luke s Hospital Mayo Clinic Princeton University known for = isolation of thyroxine discovery of cortisone awards = Lasker Award (1949) Passano …   Wikipedia

  • Edward Calvin Kendall — noun United States biochemist who discovered cortisone (1886 1972) • Syn: ↑Kendall, ↑Edward Kendall • Instance Hypernyms: ↑biochemist …   Useful english dictionary

  • Kendall — Edward Calvin …   Scientists

  • Kendall — Kendall, Edward Calvin …   Enciclopedia Universal

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