Huggins , Charles Brenton

Huggins , Charles Brenton
(1901–) Canadian–American surgeon
Huggins, who was born at Halifax in Nova Scotia, was educated at Acadia University and at the Harvard Medical School, where he obtained his MD in 1924. After graduate training at the University of Michigan he moved to the University of Chicago in 1927 where he has served as professor of surgery since 1936 and director of the May Laboratory of Cancer Research from 1951 until 1969.
In 1939 Huggins made a very simple inference that led to the development of new forms of cancer therapy. Noting that the prostate gland was under the control of androgens (male sex hormones) he concluded that cancer of the prostate might be treated by preventing the production of androgens. Admittedly his proposed treatment of orchiectomy (castration) might appear somewhat severe but it did lead to remissions in some cases and an alleviation of the condition in others.
Huggins soon appreciated however that the same results could probably be achieved by the less drastic procedure of the administration of female sex hormones to neutralize the effect of androgens produced by the testicles. Consequently in 1941 he began to inject his patients with the hormones stilbestrol and hexestrol. He was able to report later that of the first 20 patients so treated 4 were still alive after 12 years. Later workers, inspired by Huggins's work, treated women suffering from cancer of the breast with the male hormone testosterone and claimed improvement in some 20% of the cases.
It was for this work that Huggins shared the 1966 Nobel Prize for physiology or medicine with Peyton Rous.

Scientists. . 2011.

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  • Huggins,Charles Brenton — Hug·gins (hŭgʹĭnz), Charles Brenton. 1901 1997. Canadian born American surgeon. He shared a 1966 Nobel Prize for research in hormone treatment for cancer of the prostate. * * * …   Universalium

  • Huggins, Charles Brenton — ▪ 1998       Canadian born American surgeon and medical researcher (b. Sept. 22, 1901, Halifax, N.S. d. Jan. 12, 1997, Chicago, Ill.), specialized in the surgical and therapeutic treatment of cancer of the prostate and mammary glands and shared… …   Universalium

  • Charles Brenton Huggins — Born September 22, 1901 …   Wikipedia

  • Charles Brenton Huggins — Pour les articles homonymes, voir Huggins. Charles Brenton Huggins (22 septembre 1901 à Halifax, Nouvelle Écosse, Canada 12 janvier 1997 à Chicago) est un physiologiste américain, natif du Canada. Chercheur spécialiste du… …   Wikipédia en Français

  • Charles Brenton Huggins — (* 22. September 1901 in Halifax, Kanada; † 12. Januar 1997 in Chicago, USA) war ein kanadisch US amerikanischer Chirurg. Er erhielt 1963 den Albert Lasker Award for Clinical Medical Research und 1966 den Nobelpreis für Physiologie oder Medizin… …   Deutsch Wikipedia

  • Charles Brenton Huggins — Dr. Charles Brenton Huggins ( * 22 de septiembre de 1901 – 12 de enero de 1997) fue un médico, fisiólogo e investigador de cáncer estadounidense nacido en Canadá. Investigador de la Universidad de Chicago especializado en cáncer de próstata. Él y …   Wikipedia Español

  • Huggins, Charles B. — ▪ American surgeon and medical researcher in full  Charles Brenton Huggins   born Sept. 22, 1901, Halifax, Nova Scotia, Can. died Jan. 12, 1997, Chicago, Ill., U.S.  Canadian born American surgeon and urologist whose investigations demonstrated… …   Universalium

  • Charles Brenton Huggins — n. Charles Huggins (1901 1997), Canadian born American physiologist and surgeon and cancer researcher who won the Nobel Prize for Physiology or Medicine in 1966 (together with Peyton Rous) for his discovery that hormones could be used to control… …   English contemporary dictionary

  • Medizinnobelpreis 1966: Charles Brenton Huggins — Francis Peyton Rous —   Rous erhielt den Nobelpreis für »seine Entdeckung zu Tumoren erzeugenden Viren« und Huggins für »Entdeckungen zur Hormonbehandlung von Prostatakrebs«.    Biografien   Charles Brenton Huggins, * Halifax (Kanada) 22. 9. 1901, ✝ Chicago 12. 1.… …   Universal-Lexikon

  • Charles B. Huggins — Charles Brenton Huggins (* 22. September 1901 in Halifax, Kanada; † 12. Januar 1997 in Chicago, USA) war ein kanadisch US amerikanischer Chirurg. Er erhielt 1966 den Nobelpreis für Physiologie oder Medizin für seine „Entdeckungen zur… …   Deutsch Wikipedia

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