Tsui , Lap-Chee

Tsui , Lap-Chee
(1950–) Chinese–Canadian molecular biologist
Tsui was born at Shanghai in China and educated at the Chinese University, Hong Kong, and at the University of Pittsburgh, where he obtained his PhD in 1979. He joined the staff of the Hospital for Sick Children, Toronto, in 1980 and has continued to work there while also holding (since 1990) a professorship of medical genetics at the University of Toronto.
In 1989, in collaboration with his Toronto colleagues Jack Riordan and Francis Collins of the University of Michigan and against strong competition, Tsui announced that he had located the cystic fibrosis gene. Cystic fibrosis (CF) is caused by a recessive gene widely distributed among Caucasians; about 1000 children with CF are born in the United States each year. The disease affects secretory epithelia and, until recently, patients tended to die from lung infections and heart failure in their twenties.
When Tsui arrived in Toronto in 1980 new techniques were being proposed which, if effective, should allow defective genes to be identified. The procedure, introduced by Ray White and his colleagues, involved identifying an appropriate RFLP (restriction fragment length polymorphism), i.e., a fragment of DNA for use as a genetic marker to locate the site of the defective gene. The difficulty was that the human genome contains 3 billion base pairs of DNA; it was, therefore, a very remote possibility that any genetic marker would be within a reasonable distance of the CF gene. The chances would, however, be much improved if it was known on which chromosome the gene was sited. This was established as chromosome 7 by a Massachusetts biotechnology firm, Collaborative Research Inc (CRI), in 1985.
Thereafter it was a matter of using the available probes to focus on the area in which the gene could be found. By 1989 it had been narrowed to 300,000 base pairs. Further work demonstrated that the defective gene encoded a membrane protein of 1480 amino acids and has been dubbed the CF transmembrane conductance regulator (CFTR). Tsui and his colleagues have shown that a loss of one amino acid one third of the way along the gene is responsible for 68% of cases of CF. He has continued to search for the mutations responsible for the other cases and has also sought to understand at the molecular level variations in the severity of the disease.

Scientists. . 2011.

Игры ⚽ Нужно сделать НИР?

Look at other dictionaries:

  • Tsui Lap Chee — Lap Chee Tsui, OC, O.Ont (chinesisch 徐立之 Xú Lìzhī; * 31. Dezember 1950 in Shanghai) ist ein Forscher auf dem Gebiet der Genetik und Vize Präsident der Universität Hongkong. Biografie Tsui wurde in China geboren und studierte in Hong… …   Deutsch Wikipedia

  • Lap-Chee Tsui — (chin. 徐立之, Xú Lìzhī; * 31. Dezember 1950 in Shanghai) ist ein Forscher auf dem Gebiet der Genetik und Vize Präsident der Universität Hongkong. Biografie Tsui wurde in China geboren und studierte in Hong Kong an der Universität Hongkong, wo er… …   Deutsch Wikipedia

  • Lap-Chee Tsui — Infobox Person name = Lap Chee Tsui caption = birth date = birth date and age|1950|12|21 birth place = Shanghai, China occupation = Vice Chancellor, University of Hong Kong networth = spouse = children = website = footnotes =Lap Chee Tsui, O.C.,… …   Wikipedia

  • Tsui — ist der Familienname folgender Personen: Daniel Chee Tsui (* 1939), chinesisch US amerikanischer Physiker Kenneth Tsui (* 1949), hongkong chinesischer Tennisspieler Max Tsui (* 1979), deutscher Kameramann Tsui Hark (* 1951), Regisseur aus… …   Deutsch Wikipedia

  • Liste der Biografien/Ts — Biografien: A B C D E F G H I J K L M N O P Q …   Deutsch Wikipedia

  • Liste der Officers des Order of Canada/T — Officers des Order of Canada   A B C D E F G H I J K …   Deutsch Wikipedia

  • Li Ka Shing Foundation — Infobox Company | company name = Li Ka Shing Foundation company location = Hong Kong company type = Charity foundation = 1980, Hong Kong company slogan = Knowledge changes fate知識改變命運 homepage = http://www.lksf.orgThe Li Ka Shing Foundation… …   Wikipedia

  • University of Hong Kong — Infobox University name = University of Hong Kong native name = 香港大學 caption = Shield of The University of Hong Kong motto = Sapientia Et Virtus (Latin) 明徳格物 (Classical Chinese) [The Great Learning] mottoeng = Wisdom and Virtue established = 1911 …   Wikipedia

  • The Centre for Applied Genomics — Infobox Company name = The Centre for Applied Genomics type = Genome Centre foundation = 1998 location city = Toronto location country = Canada location = locations = key people = [http://www.tcag.ca/scherer/ Dr. Stephen W. Scherer] , Scientific… …   Wikipedia

  • Cystic fibrosis — Classification and external resources A breathing treatment for cystic fibrosis, using a mask nebuliser and a ThAIRapy Vest ICD 10 E …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”